Is Resveratrol An Underrated Supernutrient?

Resveratrol is a natural compound found in red wine, grapes, and berries. Lately it’s been making a splash for being an extraordinary nutritional supplement that is finally getting recognition for its anticancer properties. Even as early as 1997, there was growing speculation on how resveratrol could act as a chemopreventive agent against adverse effects of cancer on the human body. A known antioxidant and antimutagen, it showed potential to act as a suppressor for tumor organoids and preneoplastic lesions as well as to aiding in anti-inflammatory effects and cardiovascular health.

Suppressing preneoplastic lesions acts as a major preventative for future tumor growth and suppressing tumor organoids can be a reliable treatment if proven in further efficacy. There would be more trials needed throughout the decades in order to show further data to prove resveratrol’s merit. The results from these trials served not only to prove resveratrol as a potential preventative in tumor cellular growth, but also as a candidate for cardiovascular maintenance, anti-inflammatory cause, and preventing ocular degeneration.

In 2010, trials were conducted for trans-resveratrol, which is basically a highly concentrated form of resveratrol that is considered more biologically active in preventing tumor growth. The trials showed trans-resveratrol to improve cardiovascular health, reduce inflammation, and aid in neuroplasticity. In particular, Longevinex, a trans-resveratrol, showed phosphorylation which controls protein function and cell signaling. This process produced autophagy, or cellular regeneration, in these 2010 trials. Following published studies concerning resveratrol included a study showing protection against ischemia reperfusion injuries and a study evincing a reduction in cholesterol during a 6 month duration of taking the trans-resveratrol Longevinex.

This further led to studies with Longevinex, and these studies showed that through oral administration a distribution of resveratrol occurred to ocular tissues which displayed potential to treat ocular diseases.  Another study noted that a minute dosage of resveratrol showed positive correlations with progressive motility. There were also positive associations with resveratrol acting as an anti-inflammatory aid for those with Chronic Obstructive Pulmonary Disease.

Alongside this new information, resveratrol further demonstrated to possess anticancer properties. While resveratrol was correlated to guanine basis deletion and the modified structure of DNA molecules in the cell nucleus given its interaction with an abundance of copper, high copper concentration is linked to cancer growth. So apoptosis, or cell death, with change to guanine was associated with anti-cancer activity concerning resveratrol’s role.

Resveratrol was also shown to prevent mitochondrial dysfunction within intestinal cells and produce an anti-inflammatory response. Resveratrol being able to prevent inflammation in this case was connected to hindering microglia’s process in releasing pro-inflammatory factors. Microglia are a glial cell located in the central nervous system and functions related to modifying microglia and its inflammatory responses could be linked to inhibiting the development of Alzheimer’s. And a 2018 study particularly noted resveratrol’s interaction with microglia could serve as promising for preventing the onset of Alzheimer's.

A follow-up study in 2025 concluded resveratrol had anti-inflammatory effects with participants from ages 21 – 82. So there is a lot to look forward to concerning resveratrol’s applications for anti-inflammatory effects!

Two recent studies in 2025 also concluded resveratrol could have involvement in the prevention or alteration of cancer cell growth and migration. Resveratrol could possibly be involved in changing signaling between cancer cells as well as stopping cancer cellular growth and following this action with apoptosis of the cancer cell.

Depending on the dosage and application of resveratrol or trans-resveratrol like Longevinex, there could be cause for its merit in preventing inflammation, Alzheimer's disease, and cancer cellular growth.

Like with any supplements you may have questions about, please consult with your primary physician. And as always stay well, live well, and thrive on.